Lecture 3
Compartmental modeling, physical dimensions, phase diagrams, calcium influx experiment
Public resources and restricted materials are identified below. Access information.
Core Readings
- Compartmental Modeling. Chapter 2 of Cellular Biophysics and Modeling: A primer on the computational biology of excitable cells. [DOI]
- Phase Diagrams. Chapter 3 of Cellular Biophysics and Modeling: A primer on the computational biology of excitable cells. [DOI]
- Over-expression of N-type calcium channels in cortical neurons from a mouse model of Amyotrophic Lateral Sclerosis. Pieri M, Caioli S, Canu N, Mercuri NB, Guatteo E, Zona C. Exp Neurol. 2013. [PubMed] [DOI]
Slides & Notes
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Supplementary slides: Ligands, Receptors, and Rate Laws — restricted PDF
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Supplementary slides: Compartment Modeling, Phase Diagrams, Units, and Tau — restricted PDF
Practice
Further Reading & Resources
- MIT Mathlet to explore the phase line and bifurcation diagrams. [Mathlet]
- Ligands, Receptors and Rate Laws. Chapter 4 of Cellular Biophysics and Modeling: A primer on the systems biology of excitable cells. [DOI]
Restricted reading copies in the PDF companion — private repository access required.