Lecture 7
Voltage-dependent currents and bistability
Public resources and restricted materials are identified below. Access information.
Core Readings
- Voltage-Gated Ionic Currents. Chapter 10 of Cellular Biophysics and Modeling: A primer on the systems biology of excitable cells. [DOI]
- Regenerative Ionic Currents and Bistability. Chapter 11 of Cellular Biophysics and Modeling: A primer on the systems biology of excitable cells. [DOI]
- Sigworth FJ. Structural biology: Life’s transistors. Nature. 2003 May 1;423(6935):21-2. [PubMed] [DOI]
- Dolphin AC. A short history of voltage-gated calcium channels. Br J Pharmacol. 2006 Jan;147 Suppl 1(Suppl 1):S56-62. [PubMed] [DOI]
- Lipscombe D, Helton TD, Xu W. L-type calcium channels: the low down. J Neurophysiol. 2004 Nov;92(5):2633-41. [PubMed] [DOI]
- Kiehn O, Eken T. Functional role of plateau potentials in vertebrate motor neurons. Curr Opin Neurobiol. 1998 Dec;8(6):746-52. [PubMed] [DOI]
- Scholarpedia entry for Up and down states by Charles Wilson. [Scholarpedia]
Reading details
Wilson, C. Up and down states. Scholarpedia. Article
Slides & Notes
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Supplementary slides: Voltage Dependence and Bistability — restricted PDF
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Supplementary slides: Voltage-Gated Currents — restricted PDF
Recordings & Tutorials
Tutorial: Voltage-dependent currents tutorial
Practice
Restricted reading copies in the PDF companion — private repository access required.