Lecture 9
Voltage-clamp recording and the classical biophysics of the squid giant axon
Public resources and restricted materials are identified below. Access information.
Core Readings
- Voltage-Clamp Recording. Chapter 12 of Cellular Biophysics and Modeling: A primer on the computational biology of excitable cells.
- Hodgkin-Huxley Model of the Action Potential. Chapter 13 of Cellular Biophysics and Modeling: A primer on the computational biology of excitable cells.
Slides & Notes
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Supplementary slides: Voltage Clamp and Hodgkin-Huxley — part 1 — restricted PDF
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Supplementary slides: Voltage Clamp and Hodgkin-Huxley — part 2 — restricted PDF
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Supplementary slides: Voltage Clamp and Hodgkin-Huxley — part 3 — restricted PDF
Recordings & Tutorials
- Lecture 9 - Part 1 - Voltage-clamp recording and the classical biophysics of the squid giant axon
- Lecture 9 - Part 2 - Voltage-clamp recording and the classical biophysics of the squid giant axon
- Watch this video of Jim Keener on the Dynamics of the Action Potential: The Hodgkin-Huxley Macarena.
The following mathematics lectures discuss concepts from linear algebra that will be used in future lectures. These recordings introduce the linear algebra used in subsequent lectures.
- WildLinAlg5: Change of coordinates and determinants [START AT 29:34]
- WildLinAlg6: Applications of 2x2 matrices
Tutorial: Hodgkin-Huxley tutorial
Models & Demonstrations
Practice
Further Reading & Resources
- Peering into the black box. An interview with Bertill Hille, a Sounds Physiological podcast by Liz Adler, Executive Editor of the Journal of General Physiology.
- Häusser, Michael. “The Hodgkin-Huxley theory of the action potential.” Nature neuroscience 3.11 (2000): 1165-1165. (short, easy read) [DOI]
- Hille Chapter 2 “Classical biophysics of the squid giant axon” (long, but worth the effort)
- Bean, B. P. (2007). The action potential in mammalian central neurons. Nature Reviews Neuroscience, 8(6), 451-465. [DOI]
- “The Hodgkin-Huxley model” by Nelson and Rinzel. This is Ch 4 of “The Book of GENESIS: Exploring Realistic Neural Models with the GEneral NEural SImulation System” by James M. Bower and David Beeman
Restricted reading copies in the PDF companion — private repository access required.